Tim Setter
Field Crop Biologist
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513 Bradfield Hall and 235 Emerson Hall BS 1974 (Univ. Wisconsin-Madison) Food
Chemistry Tim Setter is Professor and Chair in the Section of Soil and Crop Sciences, with joint membership in the Section of Plant Breeding and Genetics. These units are in the School of Integrative Plant Science. He currently collaborates with researchers at national institutes in Nigeria (NRCRI), and Uganda (NaCRRI), and at the International Institute of Tropical Agriculture (IITA) on the NEXTGEN cassava project, which is funded by the Bill and Melinda Gates Foundation. He is a member of the Cornell Graduate Faculties in the Field of Soil and Crop Sciences and in Plant Biology. |
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Research Program "My research seeks a better understanding of the underlying biology of drought stress response and better methods to screen breeding germplasm for improved responses to environmental stresses. In cassava and maize, we are comparing diverse lines for numerous traits related to stress response such as carbohydrate storage and remobilization, and accumulation of the stress hormone ABA. In maize, we focus on reproductive and kernel development and associated yield-determining processes. These studies seek to identify traits that could serve as targets for selection in breeding programs and QTL/marker assisted selection strategies. Our research has indicated that sink organ development during cell division and primordial phases is especially responsive to environment, so we are determining the mechanisms by which environmental stresses arrest sink-organ development (especially reproductive organs: maize florets and kernels) alter phytohormone levels and modify the expression of gene products involved in cell proliferation. All of our studies deal with plant responses to environmental conditions, especially water deficit, temperature, and elevated atmospheric CO2. Studies on maize reproductive development concern the influence of water deficit on abscisic acid and cytokinin levels, on sugar fluxes in grain tissues, and regulatory proteins.We use transcript profiling to quantify gene expression, collaborate with quantitative geneticists and breeders on mapping genetic loci, and seek to ways to improve crop cultivars so farmers in drought-prone areas of the world can achieve food security." Courses Taught |
Selected Publications others Yu L-X, Setter TL (2016)
Comparative transcriptomes between viviparous1 and wildtype maize
developing endosperms in response to water deficit. Environmental and
Experimental Botany 123: 116-124 web access: click here Yu L-X, Shen X, Setter TL
(2015) Molecular and functional characterization of two drought-induced zinc
finger proteins, ZmZnF1 and ZmZnF2 from maize kernels. Environmental and
Experimental Botany 111: 13-20 web access: click here Duque LO, Setter TL (2013)
Cassava response to water deficit in deep pots: root and shoot growth, ABA,
and carbohydrate reserves in stems, leaves and storage roots. Tropical Plant
Biology 6: 199-209 web access: click here Boyer JS, Byrne P, Cassman KG,
Cooper M, Delmer D, Greene T, Gruis F, Habben J, Hausmann N, Kenny N, Lafitte
R, Paszkiewicz S, Porter D, Schlegel A, Schussler J, Setter T, Shanahan J,
Sharp RE, Vyn TJ, Warner D, Gaffney J (2013) The U.S.drought of 2012 in
perspective: A call to action. Global Food Security 2: 139-143 web access: click here Xue Y, Warburton ML, Sawkins M,
Zhang X, Setter T, Xu Y, Grudloyma P, Gethi J, Ribaut J-M, Li W, Zhang X,
Zheng Y, Yan J (2013) Genome-wide association analysis for nine agronomic
traits in maize under well-watered and water-stressed conditions. Theoretical
and Applied Genetics 126: 2587-2596 (DOI:10.1007/s00122-013-2158-x) web
access: click here Okogbenin E, Setter TL,
Ferguson M, Mutegi R, Ceballos H, Olasanmi B, Fregene M (2013) Phenotypic
approaches to drought in cassava: Review. Frontiers in Physiology 4: 93. web
access: click here Setter TL (2012) Analysis of
constituents for phenotyping drought tolerance in crop improvement. Frontiers
in Physiology 3:180. web access: click here Chen C-T, Setter TL (2012)
Response of potato dry matter assimilation and partitioning to elevated CO2
at various stages of tuber initiation and growth. Environmental and
Experimental Botany 80: 27-34. web access: click here Setter TL, Yan J, Warburton M,
Ribaut J-M, Xu Y, Sawkins M, Buckler ES, Zhang Z, Gore MA (2011) Genetic
association mapping identifies single nucleotide polymorphisms in genes that
affect abscisic acid levels in maize floral tissues during drought. Journal
of Experimental Botany 62: 701-716. web access: click here Setter TL, Parra
R (2010) Relationship of carbohydrate and abscisic acid levels to kernel set
in maize under postpollination water deficit. Crop Science 50: 980-988. web
access: click here Ribaut, J.-M., J. Betran, P.
Monneveux and T. Setter (2009) Drought Tolerance in Maize. p. 311-344 In
Handbook of Maize: Its Biology. Bennetzen, J. L. and Hake, S. C (ed.),
Springer, New York. On-line access: http://www.springerlink.com/content/978-0-387-79417-4/ Setter T.L., Fregene M.A.
(2007) Recent advances in molecular breeding of cassava for improved drought
stress tolerance. p. 701-711 In Advances in Molecular
Breeding Towards Salinity and Drought Tolerance. M.A. Jenks, P.M.
Hasegawa and S.M.Jain (ed.), Springer, New York. On-line access: http://www.springerlink.com/content/v13h781mpqp2442t/ Setter T.L. (2006) The role of
abscisic acid under water-limited conditions. pp. 505-530 In
Drought Adaptation in Cereals , J.M. Ribaut(ed.), Food Products Press,
New York. access: http://www.taylorandfrancis.com/books/details/9781560222781/ Melkonian J., Yu L.-X., Setter
T.L. (2004) Chilling responses of maize (Zea mays L.) seedlings: root
hydraulic conductance, abscisic acid, and stomatal conductance. Journal of
Experimental Botany 55: 1751-1760. web access: http://jxb.oupjournals.org/cgi/content/abstract/55/403/1751 Alves A.A.C., Setter T.L.
(2004) The Response of cassava leaf area expansion to water deficit. Cell
proliferation, cell expansion, and delayed development. Annals of Botany
94:605-613. web access: http://aob.oupjournals.org/cgi/content/abstract/94/4/605/ Alves A.A.C., Setter T.L.
(2004) Abscisic acid accumulation and osmotic adjustment in cassava under
water deficit. Environmental & Experimental Botany 51: 259-271. web
access: http://dx.doi.org/10.1016/j.envexpbot.2003.11.005 Yu L.X., Setter T.L. (2003)
Comparative transcriptional profiling of placenta and endosperm in developing
maize kernels in response to water deficit. Plant Physiology 131: 568-582
(note correction for Table I due to printer's error) web access to corrected
copy: http://www.css.cornell.edu/faculty/tls1/pp.014365v1.pdf Chen C.-T., Setter T.L. (2003)
Response of potato tuber cell division and growth to shade and elevated CO2.
Annals of Botany 91: 373-381 web access: http://aob.oxfordjournals.org/content/91/3/373.abstract Wang Z., Mambelli S., Setter
T.L. (2002) Abscisic acid catabolism in maize kernels in response to water
deficit at early endosperm development. Annals of Botany 90: 623-630. web
access: http://aob.oxfordjournals.org/content/90/5/623.abstract Setter T.L., Flannigan B.A.,
Melkonian J. (2001) Loss of kernel set due to water deficit and shade in
maize: Carbohydrate supplies, abscisic acid, and cytokinins. Crop Science 41:
1530-1540. web access: https://www.crops.org/publications/cs/abstracts/41/5/1530 Setter T.L., Flannigan B.A.
(2001) Water deficit inhibits cell division and expression of transcripts
involved in cell proliferation and endoreduplication in maize endosperm.
Journal of Experimental Botany 52(360): 1401-1408 web access: http://jxb.oxfordjournals.org/content/52/360/1401.abstract Jones R.J., Setter T.L. (2000)
Hormonal regulation of early kernel development. pp. 25-42 In
Physiology and Modeling Kernel Set in Maize, M.E. Westgate and K.J. Boote
(eds.), Crop Science Society of America, Madison, WI Alves A.A.C., Setter T.L.
(2000) Response of cassava to water deficit: leaf area growth and abscisic
acid. Crop Science 40:131-137 web access: https://www.crops.org/publications/cs/abstracts/40/1/131
Sun Y., Flannigan B.A., Setter
T.L. (1999) Regulation of endoreduplication in maize (Zea mays, L.)
endosperm. Isolation of a novel B1-type cyclin and its quantitative analysis.
Plant Molec. Biol. 41: 245-258. web access: http://www.springerlink.com/content/u38144u0n6t34534/
Mugo SN, Smith ME, Banziger M,
Setter TL, Edmeades GO, Elings A. (1998) Performance of early maturing
Katumani and Kito maize composites under drought at the seedling and
flowering stages. African Crop Sci J 6: 329-344 Mambelli S, Setter TL (1998)
Inhibition of maize endosperm cell division and endoreduplication by
exogenously applied abscisic acid. Physiol. Plant. 104: 266-272. web access: http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3054.1998.1040215.x/abstract Sun Y.J., Flannigan
B.A.,Madison J.T., Setter T.L. (1997) Alternative splicing of cyclin
transcripts in maize endosperm. Gene 195: 167-175 Artlip TS, Madison JT, Setter
TL (1995) Water deficit in developing endosperm of maize: cell division and
nuclear endoreduplication. Plant, Cell & Environment 18:1034-1040. web
access: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3040.1995.tb00614.x/abstract Setter TL (1993) Assimilate
allocation in response to water deficit stress. p. 733-739 In: DR Buxton (ed)
International Crop Science I, Chapter 97. Crop Science Society of America,
Madison Wisconsin Lur, H. S., Setter, T. L.
(1993) Role of auxin in maize endosperm development. Timing of nuclear DNA
endoreduplication, zein expression, and cytokinin. Plant Physiology
103:273-280. web access: http://www.plantphysiol.org/cgi/content/abstract/103/1/273 Myers, P.N., Setter, T.L.
Madison, J.T., Thompson, J.F. (1992) Endosperm cell division in maize kernels
cultured at three levels of water potential. Plant Physiology 99:1051-1056.
web access: http://www.plantphysiol.org/cgi/content/abstract/99/3/1051 Ober, E.S., Setter, T.L. (1992)
Water deficit induces abscisic acid accumulation in endosperm of maize
viviparous mutants. Plant Physiology 98:353-356. web access: http://www.plantphysiol.org/cgi/content/abstract/98/1/353 Ober, E.S., Setter, T.L.,
Madison, J.T., Thompson, J.F., Shapiro, P.S. (1991) Influence of water
deficit on maize endosperm development. Enzyme activities and RNA transcripts
of starch and zein synthesis, abscisic acid, and cell division. Plant
Physiology 97:154-164. web access: http://www.plantphysiol.org/cgi/content/abstract/97/1/154
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